Professional Ranks and Titles: Professor

Email Contact: huyan@cqu.edu.cn

Personal statement: (500-word limit)

Professor Hu obtained her doctoral degree of Biomedical Engineering in 2011 at Chongqing University and hosted more than 10 funding projects including General Programs/Young Scientists Programs of National Natural Science Foundation of China, General Programs of Natural Science Foundation of Chongqing and Fundamental Research founds of the Central Universities. The applicant was also a key participant in more than 10 national research projects including National Key R&D Programs, Key National Research Project of China and National Science Fund for Distinguished Young Scholars of China. The applicant has won the Natural Science Award of Chongqing (2nd place) and published more than 30 papers on journals in the first group of academic ranking by Chinese Academy of Sciences including Advanced Materials, Angew. Chem. Int. Ed, Biomaterials and Acta Biomaterialia, which have been cited by other groups for more than 3000 times. The applicant taught two classes for undergraduates and graduate students including “Biomaterials” and “Experimental techniques for biomedical materials”.

Research focus: (limited to 3 items and 200 words)

1. Modification of biomaterial interface and therapeutic evaluations against bone diseases.

2. Pathogenic mechanisms of bone disease and development of therapeutic intervention options.

3. Construction of drug delivery nanosystems and evaluations on their antitumor efficacy.

Research projects: (limited to 5 items during 2016-2020)

1. National Natural Science Foundation of China, General Program: Construction of osteoporotic microenvironment-responsive composite biointerfaces on titanium implants and performance evaluations on bone fracture repair.

2. Ministry of Science and Technology, Subproject leader of Key National Research Project of China, Construction and optimization biomaterials with antitumor and tissue regeneration capabilities.

3. Chongqing Science and Technology Bureau, General Program of the Chongqing Natural Science Foundation, Osteoporotic microenvironment-actuatable composite titanium-based biointerfaces and promotion on the repair of osteoporotic bone fractures.

4. Chongqing University, Fundamental Research Funds for the Central Universities. Construction of titanium-based interface with bone resorptive microenvironment and its promotional effect on new bone formation.

Representation publications: (limited to 5 items)

1. Chencheng Xue, Linawati Sutrisno, Menghuan Li, Wei Zhu, Yang Fei, Changhuang Liu, Xuan Wang, Kaiyong Cai, Yan Hu*, Zhong Luo*. Implantable Multifunctional Black Phosphorus Nanoformulation- deposited Biodegradable Scaffold for Combinational Photothermal/chemotherapy and Wound Healing. Biomaterials, 2020, 269, 120623. Impact factor: 10.3

2. Caiyun Mu, Ye He, Yan Hu*, Menghuan Li, Maowen Chen, Rong Wang, Yang Xiang, Zhong Luo*, Kaiyong Cai*. Construction of chemokine substance P-embedded biomimetic multilayer onto bioactive magnesium silicate-titanium implant for bone regeneration. Applied Materials Today, 2020, 20:100777. Impact factor: 8.35

3. Chen Maohua, Huang Ling, Shen Xinkun, Cai Kaiyong, Yan Hu*. Construction of multilayered molecular reservoirs on a titanium alloy implant for combinational drug delivery to promote osseointegration in osteoporotic conditions. Acta Biomaterialia, 2020, 105:304-318. Impact factor: 7.2

4. Zhong Luo, Yan Hu*, Kaiyong Cai, Xingwei Ding, Quan Zhang, Menghuan Li, Xing Ma, Beilu Zhang, Yongfei Zeng, Peizhou Li, Jinghua Li, Junjie Liu, Yanli Zhao*. Intracellular redox-activatedanticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity. Biomaterials 2014, 35, 79517962. Impact factor: 10.3

5. Yan Hu, Kaiyong Cai*, Zhong Luo, Klaus D.Jandt. Layer-by-layer assembly of β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis. Adv Mater, 2010, 22, 41464150. Impact factor: 27.4

Patents and standards (limited to 5 items)

1. Yan Hu, Maohua Chen, Zhong Luo, Kaiyong Cai. A bioactive titanium-based bone implants and preparation procedures. Patent No.: 20190888826.9

Majors and Degrees

PhD program: Biomedical engineering, biology.

Graduate program: Biomedical engineering, biology science.