【TITLE & POSITION】Senior Professor，Director of Key Laboratory of the Ministry of Education and Director of National Local Joint Engineering Laboratory, Former Dean of the College of Bioengineering

【Honorary Titles】

Fellow (FBSE): International Union of Societies for Biomaterials Science and Engineering (2023.11-)

ELSEVIERHighly Cited Chinese Researchers(the RANKING Internationally Famous Scholars) in Biomedical Engineering (2019.04- )

GLOBAL LIBRARY OF SCHOLARSTop 100000 scientists worldwide(2019- )

Stanford University & ELSEVIER World'sTop 2% Scientists(2023.10- )

State Council GovernmentSpecial Allowance recipients(2020- )

【ACADEMIC APPOINTMENTS】

Honorary Chairman: Vascular Branch of the Chinese Society of Anatomy (2023.12 -)

Chairman: Atherosclerosis Branch of Chinese Society of Pathophysiology (2021.06 -)

Chairman: Material Biomechanics Branch of the Chinese Society for Biomaterials (2022.12 -)

Life Member: World Association for Chinese Biomedical Engineers (2016-), International Chinese Musculoskeletal Research Society (ICMRS) (2019.04 -)

Vice Chairman: the Interventional Medicine Innovation Alliance of the National Radiology and Therapy Clinical Medical Research Center (2022.12- ), Vascular Branch of Chinese Society of Anatomy (2018.9 -); Professional Committee of Interventional Medicine Engineering and Biotechnology, the Interventional Medicine Branch of the Chinese Medical Doctor Association (2018.06 -), Chinese Holistic Integrative Medicine and Engineering Alliance (2018.01-)

Executive Member of the Council: Branch of Interventional Treatment of Cardiac and Brain Diseases, China Medical Device Industry Association (2017.03-2021.03), Branch of Interventional Medical Engineering of Chinese Society of Biomedical Engineering (2007.08--2015.05), Cardiovascular Biomaterials Branch of Chinese Society for Biomaterials (2015.06-), China Branch of International Society of Atherosclerosis (2015.01 -), Chongqing Biomedical Engineering Association (2006.01-).

Member of Council: Chinese Society of Biomedical Engineering (2015.12-2019.12), Chinese Society for Biomaterials (2012.6 -), the Intellectual Medical Professional Committee of the Chinese Medical Doctor Association (2018.05-), Biomechanics Branch of Chinese Society of Biomedical Engineering and Chinese Society of Mechanics (2015.03-), Rehabilitation Engineering Branch of Chinese Society of Biomedical Engineering (2016.07-), China Branch of International Society of Atherosclerosis (2011.04-2014.12), Zebrafish Branch of Chinese Society of Animals (2016.09-)

AssociateEditor: Research (2024.02-), Molecular & Cellular Biomechanics (2020-), Journal of Medical and Biological Engineering (2018-)

Executive Member of the Editorial Board: Chinese Journal of Arteriosclerosis (2014-)

Editorial Board Member: Biomedical Materials (2021-), Molecular & Cellular Biomechanics (2017-), Journal of Medical and Biological Engineering (2014-), AIMS Bioengineering (2014-), Journal of Cardiology Therapy (2014-), Chinese Journal of Arteriosclerosis (2009-2014)

Guest Editor-in-Chief, Frontiers in Pharmacology, Special Issue: Bioactive Substance-Mediated Targeted Therapy of Cardio-Cerebrovascular Diseases (2022)

【CONTACT INFORMATION】

E-mail: wanggx@cqu.edu.cn;

Website:http://bio.cqu.edu.cn/info/1164/3021.htm

【PERSONAL PROFILE】

Dr. Guixue Wang graduated from Chongqing University (Ph.D. in 1998 Major in Biomechanics). After the completion of postdoctoral research at Laval University, he joined Chongqing University in September 2000 to carry out teaching/research work.

He has undertaken a total of 46 projects at all levels, including 13 national level projects, 28 provincial and ministerial level projects, and received research funding of over 65 million yuan. He has jointly published 470 papers with domestic and foreign scholars, in which 320 are indexed by SCI and 170 are indexed by EI. His team has been authorized more than 60 domestic and international patents, and won 6 provincial and ministerial science and technology and teaching achievement awards, 3 national industry associations and societies awards.

His areas of research interest include vascular biomechanics and mechanobiology, tissue repair materials and minimally invasive interventional medical devices, which integrate research in basic theories of mechanobiology, hemodynamic mechanisms and therapeutic technologies of vascular injury repair. The hypothesis of concentration polarization of atherogenic lipids in the arterial system was first confirmed by his team using a zebrafish-mouse-rabbit model system. They developed the vascular injury repair kinetics theory and proposed a new viewpoint of vascular repair kinetics to accelerate endothelial regeneration and inhibit vascular restenosis and the recurrence of atherosclerosis. The mechanisms by which arsenic trioxide drug-eluting stents inhibit thrombosis and restenosis have been elucidated. Following the vascular repair kinetics theory, several vascular implant surface modification technologies have also been innovatively developed. For example, the technologies of asymmetric coating directional release technology, coaxial electrostatic spraying of micronanoparticles, and stable release of multilevel drug coating have made possible for double-sided asymmetry, continuous, differential and slow release of drugs inside and outside the stent and, therefore, accelerated endothelial repair and inhibit thrombosis and restenosis. These technological achievements have been translated to the product development of some medical device companies. His team helped the company create new interventional catheters and intravascular stents, benefiting nearly 3 million patients and saving 3.6 billion yuan of medical expenses in the last three years. Some achievements have won the first prize awarded by the Chongqing Municipal Government, two first prizes of science and technology progress or natural science awarded by Chongqing University, and the first prize awarded by the Chongqing Industry-University-Research Association, which he ranked first in all four awards. He also won the First Prize awarded by the China Industry-University-Research Association, which he ranked second.

He has done a lot of student training and supervision work. A total of 25 postdoctoral fellows, 60 doctoral students, and 110 master’s students were recruited and trained. Among these students, 34 graduates are now at an associate professor level, 16 professors and doctoral supervisors.

【RESEARCH INTERESTS】

Cardio-cerebral vascular biomechanics, Atherosclerosis and hemodynamics, Hemorheology, Biomedical materials, Mechanical Biology, Biochemistry and molecular biology, Biotechnology and bioengineering, Mechano-developmental biology, Nanomedicine, Neurovascular Coupling

【REPRESENTATIVE RESEARCH PROJECTS】

“Key Technologies for Functionalized Vascular/Heart Valve Materials and Prosthesis Construction” Supported by National Key R&D Program Projects, China (2023YFB3810100), 2023-2026, 15000,000 RMB

“Study on the mechanobiological mechanism and precise diagnosis and treatment of cerebrovascular diseases”, Supported by JingFeng Laboratory (Chongqing), China (jfkyjf202203001), 2022-2026, 8000,000 RMB

“Study on Cellular Mechanobiology Mechanism of Engulfment of Vascular Endothelial Cell Promoting Atherosclerosis”, Supported by Key Projects of the National Natural Science Foundation of China (No. 12032207), 2021-2025, 3,700,000 RMB

“The Role and Mechanism of Low and Oscillatory Shear Stress-downregulated TET1s Promoting Atherosclerosis Development”, Supported by the National Natural Science Foundation of China (No. 31971242), 2020-2023, 700,000 RMB

“Study on Phenotypic Regulation and Reverse Calcification Technology during Degradation Control of Vascular Endothelial and Smooth Muscle Cell”, Supported by the National Key Technology R&D Program (No. 2016YFC1102305), 2016-2020, 1,500,000 RMB

“Mechano-Biological Mechanism which Flow Shear Stress Regulates Vascular Development in Zebrafish”, Supported by the National Natural Science Foundation of China (No. 11572064), 2016-2019, 860,000 RMB

“Mechano-Biological Mechanism on In-stent Restenosis and Late Thrombosis Reduced by Mechanic Environments after Intravascular Stent Implanting”, Supported by Key Projects of the National Natural Science Foundation of China (No. 11332003), 2014-2018, as coprincipal investigator, 3,200,000 RMB

“Mechano-Biological Mechanism Underlying High Shear Stress-Promoted Angiogenesis-Induced Vulnerable Plaque Formation, Supported by the National Natural Science Foundation of China (No. 31370949), 2013-2017, 820,000 RMB

【REPRESENTATIVE PUBLICATIONS】

Tan L, Wang X, Yuan K, Yin T, Du R, Shen L, Zhu S, Yu S, Zhang H*,Wang G*. Structural and temporal dynamics analysis on drug-eluting stents: history, research hotspots and emerging trends.Bioactive Materials. 2023, 23:170-186 (IF: 18.9)

Wu H, Meng Z, Wang J, Yao G, Yang L, Zeng Z, She K, Zhao S,Wang G*, Zhang Y*, Zang G*. Aptamer functionalized cell membrane for brain and nerve cell sensing with high sensitivity and stability.Biosensors and Bioelectronics, 2023,115149（IF: 12.6）

Wang J, Xu J, Zang G, Zhang T, Wu T, Zhang H, Chen Y, Wang Y, Qin W, Zhao S, Qin E, Qiu J, Zhang X, Wen L, Wang Y,Wang G*. Trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis.Research, 2022，9839368，(IF:11.0)

Liu X, Zhao S, Tan L, Tan Y, Wang Y, Ye Z, Hou C, Xu Y, Liu S,Wang G*. Frontier and hot topics in electrochemiluminescence sensing technology based on CiteSpace bibliometric analysis.Biosens Bioelectron. 2022;201:113932.(IF: 12.6) (ESI Most Cited Papers)

Wang Y, Zhang K, Li T, Maruf A, Qin X, Luo L, Zhong Y, Qiu J, McGinty S, Pontrelli G, Liao X, Wu W*,Wang G*. Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications.Theranostics. 2021;11(1):164-180. (IF:11.6) (ESI Most Cited Papers)

Yin T*, Du R, Wang Y, Huang J, Ge S, Huang Y, Tan Y, Liu Q, Chen Z, Feng H, Du J, Wang Y*,Wang G*. Two-stage degradation and novel functional endothelium characteristics of a 3-D printed bioresorbable scaffold.Bioact Mater. 2021; 10:378-396 (IF:16.8)

Qin X, Zhang K, Qiu J*, Wang N, Qu K, Cui Y, Huang J, Luo L, Zhong Y, Tian T, Wu W, Wang Y*,Wang G*. Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress.Bioact Mater. 2021; 9:397-410 (IF:16.8)

Xu J, Wang J, Qiu J*, Liu H, Wang Y, Cui Y, Humphry R, Wang N, DurKan C, Chen Y, Lu Y, Ma Q, Wu W, Luo Y, Xiao L*,Wang G*. Nanoparticles retard immune cells recruitment in vivo by inhibiting chemokine expression.Biomaterials. 2021; 265:120392. (IF: 15.3)

Zhou T, Zheng Y*, Sun L, Badea SR, Jin Y, Liu Y, Rolfe AJ, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw TL, Wu W,Wang G*, Ren Y*. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury.Nature Neuroscience. 2019, 22 (3): 421-435. (IF: 21.1) (ESI Most Cited Papers)

Wang Y, Zhang K, Qin X, Li T, Qiu J, Yin T, Huang J, McGinty S, Pontrelli G, Ren J, Wang Q, Wu W*,Wang G*. Biomimetic nanotherapies: red blood cell based core-shell structured nanocomplexes for atherosclerosis management.Advanced Science. 2019, 6 (12): 1900172. (IF: 15.8) (ESI Most Cited Papers)